Autoimmune diseases

AUTOIMMUNE

No definition available.

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	429209
1. Apply sex-specific rule None	429209
2. Check conditions None	429209
3. Check pre-conditions, main-only, mode, registry filters None 0 out of 7 registries used, show all original rules.	0
4. Check minimum number of events None	0
5. Include endpoints M13_RHEUMA M13_RELAPSPOLYCHONDR SLE_FG M13_SJOGREN M13_SYSTSLCE M13_DERMATOPOLY M13_WEGENER M13_MICROPOLYANG M13_CHURGSTRAUSS D3_ALLERGPURPURA I9_RHEUFEV E4_HYTHY_AI_STRICT G6_MS E4_DM1 G6_ADEM G6_DISSOTH G6_NARCOCATA AUTOIMMUNE_HYPERTHYROIDISM E4_THYROIDITAUTOIM E4_AUTOPOLYFAI AUTOHEP D3_AIHA_DRUG D3_AIHA_OTHER G6_MYASTHENIA G6_OTHDEMYEL G6_MYOMUSCINOTH K11_COELIAC CHIRBIL_PRIM G6_GUILBAR K11_IBD L12_PSORIASIS L12_VITILIGO L12_ALOPECAREATA D3_ITP N14_HENOCHSCHONLEIN_NEPHRITIS E4_ADDISON M13_HYPERANG N14_IGA_NEPHROPATHY D3_ANAEMIA_B12_DEF H7_IRIDOCYC_ANTER E4_GRAVES_OPHT_STRICT M13_BEHCET L12_PEMPHIGOID L12_DERMATHERP M13_MCTD	109384
6. Filter based on genotype QC (FinnGen only)	105676

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF5

NAME	AUTOIMMUNE
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	M13_RHEUMA\|M13_RELAPSPOLYCHONDR\|SLE_FG\|M13_SJOGREN\|M13_SYSTSLCE\|M13_DERMATOPOLY\|M13_WEGENER\|M13_MICROPOLYANG\|M13_CHURGSTRAUSS\|D3_ALLERGPURPURA\|I9_RHEUFEV\|E4_HYTHY_AI_STRICT\|G6_MS\|E4_DM1\|G6_ADEM\|G6_DISSOTH\|G6_NARCOCATA\|AUTOIMMUNE_HYPERTHYROIDISM\|E4_THYROIDITAUTOIM\|E4_AUTOPOLYFAI\|AUTOHEP\|D3_AIHA_DRUG\|D3_AIHA_OTHER\|G6_MYASTHENIA\|G6_OTHDEMYEL\|G6_MYOMUSCINOTH\|K11_COELIAC\|CHIRBIL_PRIM\|G6_GUILBAR\|K11_IBD\|L12_PSORIASIS\|L12_VITILIGO\|L12_ALOPECAREATA\|D3_ITP\|N14_HENOCHSCHONLEIN_NEPHRITIS\|E4_ADDISON\|M13_HYPERANG\|N14_IGA_NEPHROPATHY\|D3_ANAEMIA_B12_DEF\|H7_IRIDOCYC_ANTER\|E4_GRAVES_OPHT_STRICT\|M13_BEHCET\|L12_PEMPHIGOID\|L12_DERMATHERP\|M13_MCTD
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Autoimmune diseases based on the number of shared cases.

Broader endpoints:

Used for control exclusion in common control thyroid runs

Narrower endpoints:

Case counts by codes

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FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1009829	641266	360292
Only index persons	867407	566020	301387
Unadjusted period prevalence (%)
Whole population	15.33	18.37	10.07
Only index persons	17.58	20.81	11.50
Median age at first event (years)
Whole population	51.93	52.41	50.97
Only index persons	49.95	50.61	48.70

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	105676	69103	36573
Unadjusted period prevalence (%)	26.58	30.01	20.12
Median age at first event (years)	49.37	47.63	52.67

≡ Risteys

FR+FG R10

FinnGen Risteys R10

FinnGen Risteys R9

FinnGen Risteys R8

FinnGen Risteys R7

FinnGen Risteys R6

FinnGen Risteys R5

FinnGen Risteys R4

FinnGen Risteys R3

Autoimmune diseases

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints