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Dermatitis herpetiformis

DOID EFO Endpoint Browser PheWeb

L12_DERMATHERP

dermatitis herpetiformis: Dermatitis herpetiformis (DH) is a chronic autoimmune subepidermal bullous disease characterized by grouped pruritic lesions such as papules, urticarial plaques, erythema, and herpetiform vesiculae, with a predominantly symmetrical distribution on extensor surfaces of the elbows (90%), knees (30%), shoulders, buttocks, sacral region, and face of children and adults. Erosions, excoriations and hyperpigmentation usually follow. DH may also appear as a consequence of gluten intolerance.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L13.0
  • Hospital discharge: ICD-9 — 6940A|6942
  • Hospital discharge: ICD-8 — 693
  • Cause of death: ICD-10 — L13.0
  • Cause of death: ICD-9 — 6940A|6942
  • Cause of death: ICD-8 — 693

2 out of 7 registries used, show all original rules.

541

4. Check minimum number of events

None

541

5. Include endpoints

None

541

6. Filter based on genotype QC (FinnGen only)

530

Control definitions (FinnGen only)

Control exclude L12_BULLOUS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L13
Name in latin Dermatitis herpetiformis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4875 2511 2338
Only index persons 4281 2269 2012
Unadjusted period prevalence (%)
Whole population 0.07 0.07 0.07
Only index persons 0.08 0.08 0.08
Median age at first event (years)
Whole population 45.74 45.97 45.38
Only index persons 44.15 44.66 43.57

-FinnGen-

Key figures

All Female Male
Number of individuals 530 288 242
Unadjusted period prevalence (%) 0.13 0.13 0.13
Median age at first event (years) 45.03 42.09 48.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: L12_DERMATHERP – Dermatitis herpetiformis

GWS hits: 2

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