rheumatic fever: Rheumatic fever (RF) is a multisystem inflammatory disease occurring as a post-infectious, nonsuppurative sequela of untreated streptococcus pyogenes (Group A streptococcus [GAS]) pharyngitis, and mainly occurs in individuals aged 5 to 15 years. The most common presenting signs are fever, migratory polyarthritis and carditis.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditionsNone |
429209 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
1079 |
6. Filter based on genotype QC (FinnGen only) |
1034 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Rheumatic fever incl heart disease
based on the number of shared cases.
Broader endpoints:
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
Narrower endpoints:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 20505 | 10490 | 9486 |
| Only index persons | 9214 | 4842 | 4372 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.29 | 0.30 | 0.27 |
| Only index persons | 0.17 | 0.18 | 0.17 |
| Median age at first event (years) | |||
| Whole population | 61.81 | 65.18 | 57.95 |
| Only index persons | 51.22 | 55.20 | 46.81 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1034 | 463 | 571 |
| Unadjusted period prevalence (%) | 0.26 | 0.20 | 0.31 |
| Median age at first event (years) | 52.28 | 46.88 | 56.65 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Relationships between endpoints
↥Index endpoint: I9_RHEUFEV – Rheumatic fever incl heart disease
GWS hits: -
Loading Relationships table