rheumatic fever: Rheumatic fever (RF) is a multisystem inflammatory disease occurring as a post-infectious, nonsuppurative sequela of untreated streptococcus pyogenes (Group A streptococcus [GAS]) pharyngitis, and mainly occurs in individuals aged 5 to 15 years. The most common presenting signs are fever, migratory polyarthritis and carditis.
Rheumatic fever without mention of heart involvement
DOID EFO Endpoint Browser PheWeb
I9_RHEUFEVWITHOUTHEART
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditionsNone |
429209 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
104 |
4. Check minimum number of eventsNone |
104 |
5. Include endpointsNone |
104 |
6. Filter based on genotype QC (FinnGen only) |
103 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Rheumatic fever without mention of heart involvement
based on the number of shared cases.
Broader endpoints:
- Rheumatic fever incl heart disease
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
Narrower endpoints:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1291 | 714 | 563 |
| Only index persons | 971 | 550 | 421 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 36.50 | 39.46 | 32.27 |
| Only index persons | 30.76 | 33.43 | 27.27 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 103 | 55 | 48 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 27.48 | 27.46 | 27.50 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Relationships between endpoints
↥Index endpoint: I9_RHEUFEVWITHOUTHEART – Rheumatic fever without mention of heart involvement
GWS hits: -
Loading Relationships table