rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditionsNone |
429209 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
14002 |
4. Check minimum number of eventsNone |
14002 |
5. Include endpointsNone |
14002 |
6. Filter based on genotype QC (FinnGen only) |
13620 |
Control definitions (FinnGen only)
Control exclude
M13_ARTHROPATHIES
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to Rheumatoid arthritis based on the number of shared cases.
Broader endpoints:
- Rheumatoid arthritis , including avohilmo
- Polyarthropathies
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Arthropathies
Narrower endpoints:
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 122129 | 82772 | 38172 |
Only index persons | 94097 | 65400 | 28697 |
Unadjusted period prevalence (%) | |||
Whole population | 1.95 | 2.37 | 1.07 |
Only index persons | 2.01 | 2.40 | 1.10 |
Median age at first event (years) | |||
Whole population | 56.51 | 56.02 | 57.52 |
Only index persons | 54.66 | 54.03 | 56.10 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 13620 | 9151 | 4469 |
Unadjusted period prevalence (%) | 3.48 | 3.97 | 2.46 |
Median age at first event (years) | 53.25 | 51.29 | 57.26 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Relationships between endpoints
↥Index endpoint: M13_RHEUMA – Rheumatoid arthritis
GWS hits: 25
Loading Relationships table