rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditionsNone |
429209 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
4302 |
4. Check minimum number of eventsNone |
4302 |
5. Include endpointsNone |
4302 |
6. Filter based on genotype QC (FinnGen only) |
4192 |
Control definitions (FinnGen only)
Control exclude
RHEUMA_ENDPOINTS
Extra metadata
First used in FinnGen datafreeze
DF3
Parent code in ICD-10
M06
Name in latin
Arthritis rheumatoides seronegativa
Similar endpoints
↥List of similar endpoints to
Seronegative rheumatoid arthritis
based on the number of shared cases.
Broader endpoints:
- Other (seronegative) rheumatoid arthritis, wide
- Rheumatoid arthritis
- Rheumatoid arthritis , including avohilmo
- Polyarthropathies
- Finngen Rheumatological endpoints
Narrower endpoints:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 32653 | 23007 | 9442 |
| Only index persons | 27640 | 19750 | 7890 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.54 | 0.66 | 0.26 |
| Only index persons | 0.60 | 0.73 | 0.30 |
| Median age at first event (years) | |||
| Whole population | 58.77 | 58.03 | 60.42 |
| Only index persons | 56.74 | 56.04 | 58.50 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4192 | 2959 | 1233 |
| Unadjusted period prevalence (%) | 1.11 | 1.28 | 0.68 |
| Median age at first event (years) | 54.66 | 52.82 | 59.09 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Relationships between endpoints
↥Index endpoint: RHEUMA_SERONEG – Seronegative rheumatoid arthritis
GWS hits: 4
Loading Relationships table