rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditionsNone |
429209 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
6872 |
4. Check minimum number of eventsNone |
6872 |
5. Include endpointsNone |
6872 |
6. Filter based on genotype QC (FinnGen only) |
6693 |
Control definitions (FinnGen only)
Control exclude
STILL_ADULT
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M05-M14
Name in latin
Alia arthritis rheumatoides
Similar endpoints
↥List of similar endpoints to
Other (seronegative) rheumatoid arthritis, wide
based on the number of shared cases.
Broader endpoints:
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Narrower endpoints:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 60222 | 41926 | 17806 |
| Only index persons | 48566 | 34272 | 14294 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.99 | 1.20 | 0.50 |
| Only index persons | 1.05 | 1.26 | 0.55 |
| Median age at first event (years) | |||
| Whole population | 63.04 | 62.92 | 63.16 |
| Only index persons | 59.79 | 59.42 | 60.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 6693 | 4545 | 2148 |
| Unadjusted period prevalence (%) | 1.72 | 1.97 | 1.18 |
| Median age at first event (years) | 56.28 | 53.95 | 61.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Relationships between endpoints
↥Index endpoint: RHEUMA_OTHER_WIDE – Other (seronegative) rheumatoid arthritis, wide
GWS hits: 5
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