Adult-onset Still disease

STILL_ADULT

adult-onset Still's disease: adult-onset Still disease (AOSD) is a rare inflammatory multisystem disorder characterized clinically by fever of unknown origin, arthralgia or arthritis, hyperleucocytosis, and typical skin rash.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M06.1
  • Cause of death: ICD-10 M06.1

2 out of 7 registries used, show all original rules.

132

4. Check minimum number of events

None

132

5. Include endpoints

None

132

6. Filter based on genotype QC (FinnGen only)

125

Control definitions (FinnGen only)

Control exclude ILD_SYST_AUTO_DISEASES

Extra metadata

First used in FinnGen datafreeze DF5
Parent code in ICD-10 M06
Name in latin Arthritis rheumatoides seronegativa

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 695 385 303
Only index persons 637 353 284
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 49.30 49.81 48.68
Only index persons 47.00 47.43 46.47

-FinnGen-

Key figures

All Female Male
Number of individuals 125 76 49
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 46.14 43.75 49.85

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: STILL_ADULT – Adult-onset Still disease

GWS hits: -

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