Other/unspecified seropositive rheumatoid arthritis

RHEUMA_SEROPOS_OTH

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M05.8, M05.9
  • Hospital discharge: ICD-9 7140A
  • Cause of death: ICD-10 M05.8, M05.9
  • Cause of death: ICD-9 7140A

2 out of 7 registries used, show all original rules.

10134

4. Check minimum number of events

None

10134

5. Include endpoints

None

10134

6. Filter based on genotype QC (FinnGen only)

9866

Control definitions (FinnGen only)

Control exclude RHEUMA_SEROPOS

Extra metadata

First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 84300 58425 25065
Only index persons 65706 46757 18949
Unadjusted period prevalence (%)
Whole population 1.38 1.67 0.70
Only index persons 1.43 1.72 0.72
Median age at first event (years)
Whole population 60.02 59.71 60.57
Only index persons 57.19 56.84 58.03

-FinnGen-

Key figures

All Female Male
Number of individuals 9866 6754 3112
Unadjusted period prevalence (%) 2.55 2.93 1.71
Median age at first event (years) 55.03 53.09 59.27

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: RHEUMA_SEROPOS_OTH – Other/unspecified seropositive rheumatoid arthritis

GWS hits: 35

loading spinner Loading Relationships table