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Seropositive rheumatoid arthritis, wide

DOID EFO Endpoint Browser PheWeb

RHEUMA_SEROPOS_WIDE

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M05
  • Hospital discharge: ICD-9 — 7140A|7141
  • Cause of death: ICD-10 — M05
  • Cause of death: ICD-9 — 7140A|7141

2 out of 7 registries used, show all original rules.

10252

4. Check minimum number of events

None

10252

5. Include endpoints

None

10252

6. Filter based on genotype QC (FinnGen only)

9979

Control definitions (FinnGen only)

Control exclude RHEUMA_SEROPOS

Extra metadata

First used in FinnGen datafreeze DF3
Parent code in ICD-10 M05-M14
Name in latin Arthritis rheumatoides seropositiva

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 85545 59182 25538
Only index persons 66718 47387 19331
Unadjusted period prevalence (%)
Whole population 1.39 1.70 0.71
Only index persons 1.45 1.74 0.74
Median age at first event (years)
Whole population 60.05 59.77 60.55
Only index persons 57.21 56.88 58.01

-FinnGen-

Key figures

All Female Male
Number of individuals 9979 6825 3154
Unadjusted period prevalence (%) 2.58 2.96 1.73
Median age at first event (years) 55.04 53.09 59.25

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: RHEUMA_SEROPOS_WIDE – Seropositive rheumatoid arthritis, wide

GWS hits: 35

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