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Vitamin B12 deficiency anaemia

DOID EFO Endpoint Browser PheWeb

D3_ANAEMIA_B12_DEF

vitamin B12 deficiency: A disease characterized by low serum levels of vitamin B12, either inherited or acquired.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D51
  • Hospital discharge: ICD-9 — 281[0-1]
  • Hospital discharge: ICD-8 — 281[0-1]
  • Cause of death: ICD-10 — D51
  • Cause of death: ICD-9 — 281[0-1]
  • Cause of death: ICD-8 — 281[0-1]
  • KELA reimbursements: KELA codes — 107

3 out of 7 registries used, show all original rules.

3827

4. Check minimum number of events

None

3827

5. Include endpoints

None

3827

6. Filter based on genotype QC (FinnGen only)

3694

Control definitions (FinnGen only)

Control exclude D3_NUTRIANAEMIA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D50-D53
Name in latin Anaemia ex deficientia vitamini B12

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 52228 29010 22438
Only index persons 35116 20477 14639
Unadjusted period prevalence (%)
Whole population 0.74 0.83 0.63
Only index persons 0.67 0.75 0.56
Median age at first event (years)
Whole population 69.57 69.67 69.40
Only index persons 67.32 66.96 67.81

-FinnGen-

Key figures

All Female Male
Number of individuals 3694 1856 1838
Unadjusted period prevalence (%) 0.91 0.81 1.01
Median age at first event (years) 61.85 57.34 66.39

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: D3_ANAEMIA_B12_DEF – Vitamin B12 deficiency anaemia

GWS hits: 10

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