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Sicca syndrome [Sjögren]

DOID EFO Endpoint Browser PheWeb

M13_SJOGREN

Sjogren syndrome: an autoimmune disorder in which immune cells attack and destroy the glands that produce tears and saliva. Sjögren syndrome is also associated with rheumatic disorders such as rheumatoid arthritis or systemic lupus erythematosus. The hallmark symptoms of Sjögren syndrome are dry mouth and dry eyes. In addition, Sjogren syndrome may cause skin, nose, and vaginal dryness. It also may affect other organs of the body including the kidneys, blood vessels, lungs, liver, pancreas, and brain

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M35.0
  • Hospital discharge: ICD-9 — 7102
  • Hospital discharge: ICD-8 — 73490
  • Cause of death: ICD-10 — M35.0
  • Cause of death: ICD-9 — 7102
  • Cause of death: ICD-8 — 73490

2 out of 7 registries used, show all original rules.

2805

4. Check minimum number of events

None

2805

5. Include endpoints

None

2805

6. Filter based on genotype QC (FinnGen only)

2735

Control definitions (FinnGen only)

Control exclude M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M35
Name in latin Syndroma Sjögren

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 19087 16406 2577
Only index persons 17279 15035 2244
Unadjusted period prevalence (%)
Whole population 0.41 0.47 0.07
Only index persons 0.49 0.55 0.09
Median age at first event (years)
Whole population 56.27 56.12 57.14
Only index persons 55.36 55.28 55.90

-FinnGen-

Key figures

All Female Male
Number of individuals 2735 2366 369
Unadjusted period prevalence (%) 0.92 1.03 0.20
Median age at first event (years) 53.96 53.25 58.53

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: M13_SJOGREN – Sicca syndrome [Sjögren]

GWS hits: 4

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