connective tissue disease: A disorder characterized by abnormalities in one or more of the elements of the connective tissues, typically associated with genetic defects.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditionsNone |
429209 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
13211 |
6. Filter based on genotype QC (FinnGen only) |
12826 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Systemic connective tissue disorders
based on the number of shared cases.
Broader endpoints:
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Narrower endpoints:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 114324 | 81358 | 32067 |
| Only index persons | 95641 | 69607 | 26034 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.92 | 2.33 | 0.90 |
| Only index persons | 2.13 | 2.56 | 0.99 |
| Median age at first event (years) | |||
| Whole population | 62.72 | 61.60 | 65.43 |
| Only index persons | 60.45 | 59.02 | 64.27 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 12826 | 9160 | 3666 |
| Unadjusted period prevalence (%) | 3.42 | 3.98 | 2.02 |
| Median age at first event (years) | 57.55 | 54.35 | 65.53 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Relationships between endpoints
↥Index endpoint: M13_SYSTCONNECT – Systemic connective tissue disorders
GWS hits: 11
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