Polyarteritis Nodosa: ['A necrotizing vasculitis that affects medium-sized arteries, it is usually idiopathic, and may be triggered by viral infections (Hepatitis B, also others). A multisystem disease, it most commonly affects skin (nodules, livedo reticularis) and peripheral nerves; higher morbidity is associated with gastrointestinal, central nervous system, cardiac, and/or other organ involvement. Anti-neutrophil cytoplasmic antibodies (ANCA) are typically negative. [ NCI ]']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditionsNone |
429209 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
387 |
4. Check minimum number of eventsNone |
387 |
5. Include endpoints |
421 |
6. Filter based on genotype QC (FinnGen only) |
407 |
Control definitions (FinnGen only)
Control exclude
M13_SYSTCONNECT
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M30-M36
Name in latin
Polyarteritis nodosa et condiciones cognatae
Similar endpoints
↥List of similar endpoints to
Polyarteritis nodosa and related conditions
based on the number of shared cases.
Broader endpoints:
- Systemic connective tissue disorders
- Autoimmune diseases related-to ILD
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Narrower endpoints:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5194 | 2773 | 2381 |
| Only index persons | 3827 | 2036 | 1791 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.08 | 0.07 |
| Only index persons | 0.07 | 0.07 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 43.91 | 57.85 | 27.24 |
| Only index persons | 38.04 | 54.00 | 19.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 407 | 236 | 171 |
| Unadjusted period prevalence (%) | 0.10 | 0.10 | 0.09 |
| Median age at first event (years) | 53.38 | 51.94 | 55.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Relationships between endpoints
↥Index endpoint: M13_POLYARTERETAL – Polyarteritis nodosa and related conditions
GWS hits: -
Loading Relationships table