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Polyarteritis nodosa

DOID EFO Endpoint Browser PheWeb

M13_POLNODOSA

Polyarteritis Nodosa: ['A necrotizing vasculitis that affects medium-sized arteries, it is usually idiopathic, and may be triggered by viral infections (Hepatitis B, also others). A multisystem disease, it most commonly affects skin (nodules, livedo reticularis) and peripheral nerves; higher morbidity is associated with gastrointestinal, central nervous system, cardiac, and/or other organ involvement. Anti-neutrophil cytoplasmic antibodies (ANCA) are typically negative. [ NCI ]']

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M30.0
  • Hospital discharge: ICD-9 — 4460A
  • Hospital discharge: ICD-8 — 4460
  • Cause of death: ICD-10 — M30.0
  • Cause of death: ICD-9 — 4460A
  • Cause of death: ICD-8 — 4460

2 out of 7 registries used, show all original rules.

202

4. Check minimum number of events

None

202

5. Include endpoints

None

202

6. Filter based on genotype QC (FinnGen only)

199

Control definitions (FinnGen only)

Control exclude M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M30
Name in latin Polyarteritis nodosa

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2412 1441 939
Only index persons 1633 982 651
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.03
Only index persons 0.03 0.04 0.02
Median age at first event (years)
Whole population 66.80 70.69 60.69
Only index persons 61.28 64.65 56.21

-FinnGen-

Key figures

All Female Male
Number of individuals 199 109 90
Unadjusted period prevalence (%) 0.05 0.05 0.05
Median age at first event (years) 57.94 55.90 60.40

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: M13_POLNODOSA – Polyarteritis nodosa

GWS hits: -

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