autoimmune thyroid disease: Inflammatory disease of the thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. The clinical signs can range from hypothyroidism to thyrotoxicosis depending on the type of autoimmune thyroiditis.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditionsNone |
429209 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
551 |
4. Check minimum number of eventsNone |
551 |
5. Include endpointsNone |
551 |
6. Filter based on genotype QC (FinnGen only) |
539 |
Control definitions (FinnGen only)
Control exclude
E4_THYROID
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E06
Name in latin
Thyreoiditis autoimmunis
Similar endpoints
↥List of similar endpoints to
Autoimmune thyroiditis
based on the number of shared cases.
Broader endpoints:
- Thyroiditis
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
Narrower endpoints:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5469 | 4605 | 837 |
| Only index persons | 5134 | 4357 | 777 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.13 | 0.02 |
| Only index persons | 0.14 | 0.16 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 38.53 | 38.87 | 36.49 |
| Only index persons | 38.30 | 38.64 | 36.40 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 539 | 465 | 74 |
| Unadjusted period prevalence (%) | 0.18 | 0.20 | 0.04 |
| Median age at first event (years) | 44.49 | 43.61 | 50.02 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Relationships between endpoints
↥Index endpoint: E4_THYROIDITAUTOIM – Autoimmune thyroiditis
GWS hits: 2
Loading Relationships table