thyroid nodule: A small circumscribed mass in the THYROID GLAND that can be of neoplastic growth or non-neoplastic abnormality. It lacks a well-defined capsule or glandular architecture. Thyroid nodules are often benign but can be malignant. The growth of nodules can lead to a multinodular goiter (GOITER, NODULAR).
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditionsNone |
429209 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
32581 |
4. Check minimum number of eventsNone |
32581 |
5. Include endpoints
|
64655 |
6. Filter based on genotype QC (FinnGen only) |
62462 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Disorders of the thyroid gland
based on the number of shared cases.
Broader endpoints:
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Narrower endpoints:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 566613 | 446419 | 116533 |
| Only index persons | 517238 | 412052 | 105186 |
| Unadjusted period prevalence (%) | |||
| Whole population | 10.77 | 12.79 | 3.26 |
| Only index persons | 12.88 | 15.15 | 4.02 |
| Median age at first event (years) | |||
| Whole population | 54.73 | 53.73 | 58.77 |
| Only index persons | 53.71 | 52.65 | 57.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 62462 | 49419 | 13043 |
| Unadjusted period prevalence (%) | 18.48 | 21.46 | 7.17 |
| Median age at first event (years) | 52.10 | 50.10 | 59.66 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Relationships between endpoints
↥Index endpoint: E4_THYROID – Disorders of the thyroid gland
GWS hits: 126
Loading Relationships table