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Thyrotoxicosis, other and/or unspecified


Thyrotoxicosis: A hypermetabolic syndrome caused by the elevation of thyroid hormone levels in the serum. Signs and symptoms include tachycardia, palpitations, tremor, weight loss, warm weather intolerance, and moist skin. Causes include Graves disease, toxic nodular goiter, toxic thyroid nodule, and lymphocytic thyroiditis.

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Endpoint definition

Endpoint definition steps


Phenotype data


1. Apply sex-specific rule



2. Check conditions



3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E05[4-9]
  • Hospital discharge: ICD-9 2423
  • Hospital discharge: ICD-8 2422
  • Cause of death: ICD-10 E05[4-9]
  • Cause of death: ICD-9 2423
  • Cause of death: ICD-8 2422
  • Medicine purchases: ATC H03B

3 out of 7 registries used, show all original rules.


4. Check minimum number of events

Min. number of events 3

5. Include endpoints



6. Filter based on genotype QC (FinnGen only)


Control definitions (FinnGen only)

Control exclude E4_THYROID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics


This endpoint is excluded from FinRegistry analyses (omitted endpoint).


Key figures

All Female Male
Number of individuals 6967 5450 1517
Unadjusted period prevalence (%) 2.03 2.37 0.83
Median age at first event (years) 53.37 51.46 60.25


Age distribution of first events


Year distribution of first events


Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: E4_THYTOXNAS – Thyrotoxicosis, other and/or unspecified

GWS hits: -

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