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Thyrotoxicosis, other and/or unspecified

DOID Endpoint Browser

E4_THYTOXNAS

Thyrotoxicosis: A hypermetabolic syndrome caused by the elevation of thyroid hormone levels in the serum. Signs and symptoms include tachycardia, palpitations, tremor, weight loss, warm weather intolerance, and moist skin. Causes include Graves disease, toxic nodular goiter, toxic thyroid nodule, and lymphocytic thyroiditis.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E05[4-9]
  • Hospital discharge: ICD-9 — 2423
  • Hospital discharge: ICD-8 — 2422
  • Cause of death: ICD-10 — E05[4-9]
  • Cause of death: ICD-9 — 2423
  • Cause of death: ICD-8 — 2422
  • Medicine purchases: ATC — H03B

3 out of 7 registries used, show all original rules.

7212

4. Check minimum number of events

Min. number of events 3
7212

5. Include endpoints

None

7212

6. Filter based on genotype QC (FinnGen only)

6967

Control definitions (FinnGen only)

Control exclude E4_THYROID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 6967 5450 1517
Unadjusted period prevalence (%) 2.03 2.37 0.83
Median age at first event (years) 53.37 51.46 60.25

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

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This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: E4_THYTOXNAS – Thyrotoxicosis, other and/or unspecified

GWS hits: -

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