goiter: Enlargement of the thyroid gland usually caused by lack of iodine in the diet, hyperthyroidism, or thyroid nodules. Symptoms include difficulty in breathing and swallowing.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditionsNone |
429209 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2632 |
4. Check minimum number of eventsNone |
2632 |
5. Include endpointsNone |
2632 |
6. Filter based on genotype QC (FinnGen only) |
2543 |
Control definitions (FinnGen only)
Control exclude
E4_THYROID
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other and/or unspecified nontoxic goitre
based on the number of shared cases.
Broader endpoints:
- Nontoxic goitre/thyroid nodule
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Narrower endpoints:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 22270 | 18757 | 3408 |
| Only index persons | 20487 | 17456 | 3031 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.47 | 0.54 | 0.10 |
| Only index persons | 0.56 | 0.64 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 57.28 | 56.61 | 61.03 |
| Only index persons | 56.26 | 55.63 | 59.94 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2543 | 2134 | 409 |
| Unadjusted period prevalence (%) | 0.81 | 0.93 | 0.22 |
| Median age at first event (years) | 54.20 | 52.75 | 61.75 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Relationships between endpoints
↥Index endpoint: E4_GOITRENAS – Other and/or unspecified nontoxic goitre
GWS hits: 16
Loading Relationships table