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Nontoxic multinodular goitre

DOID EFO Endpoint Browser PheWeb

E4_GOITREMULTINOD

nodular goiter: Goiter characterized by discrete tissue mass(es) that may or may not produce thyroid hormones.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E04.2
  • Hospital discharge: ICD-9 — 2411
  • Hospital discharge: ICD-8 — 241
  • Cause of death: ICD-10 — E04.2
  • Cause of death: ICD-9 — 2411
  • Cause of death: ICD-8 — 241

2 out of 7 registries used, show all original rules.

6924

4. Check minimum number of events

None

6924

5. Include endpoints

None

6924

6. Filter based on genotype QC (FinnGen only)

6699

Control definitions (FinnGen only)

Control exclude E4_THYROID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E04
Name in latin Struma atoxica multinodularis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 61722 52630 8754
Only index persons 53558 46255 7303
Unadjusted period prevalence (%)
Whole population 1.32 1.51 0.24
Only index persons 1.51 1.70 0.28
Median age at first event (years)
Whole population 53.21 52.57 57.09
Only index persons 52.22 51.51 56.67

-FinnGen-

Key figures

All Female Male
Number of individuals 6699 5635 1064
Unadjusted period prevalence (%) 2.15 2.45 0.59
Median age at first event (years) 52.19 50.82 59.44

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: E4_GOITREMULTINOD – Nontoxic multinodular goitre

GWS hits: 44

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