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Hypothyroidism due to medicaments and other exogenous substances

DOID EFO Endpoint Browser PheWeb

E4_HYTHYSUBS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E03.2#
  • Hospital discharge: ICD-9 — 2443
  • Cause of death: ICD-10 — E03.2#
  • Cause of death: ICD-9 — 2443

2 out of 7 registries used, show all original rules.

289

4. Check minimum number of events

None

289

5. Include endpoints

None

289

6. Filter based on genotype QC (FinnGen only)

280

Control definitions (FinnGen only)

Control exclude E4_THYROID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E03
Name in latin Hypothyreosis ex medicamentis sive aliis substantiis externis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2311 1701 600
Only index persons 2080 1546 534
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.02
Only index persons 0.05 0.06 0.02
Median age at first event (years)
Whole population 61.87 61.63 62.70
Only index persons 60.73 60.33 61.91

-FinnGen-

Key figures

All Female Male
Number of individuals 280 202 78
Unadjusted period prevalence (%) 0.08 0.09 0.04
Median age at first event (years) 57.29 55.17 62.80

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: E4_HYTHYSUBS – Hypothyroidism due to medicaments and other exogenous substances

GWS hits: -

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