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Adrenocortical insufficiency

DOID EFO Endpoint Browser PheWeb

E4_ADDISON

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E27.1, E27.2, E27.3#, E27.4
  • Hospital discharge: ICD-9 — 2554
  • Hospital discharge: ICD-8 — 2551
  • Cause of death: ICD-10 — E27.1, E27.2, E27.3#, E27.4
  • Cause of death: ICD-9 — 2554
  • Cause of death: ICD-8 — 2551
  • KELA reimbursements: KELA codes — 105

3 out of 7 registries used, show all original rules.

1035

4. Check minimum number of events

None

1035

5. Include endpoints

None

1035

6. Filter based on genotype QC (FinnGen only)

1002

Control definitions (FinnGen only)

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7708 4664 2983
Only index persons 6408 3987 2421
Unadjusted period prevalence (%)
Whole population 0.11 0.13 0.08
Only index persons 0.13 0.15 0.09
Median age at first event (years)
Whole population 52.50 53.53 50.87
Only index persons 52.56 53.14 51.61

-FinnGen-

Key figures

All Female Male
Number of individuals 1002 669 333
Unadjusted period prevalence (%) 0.25 0.29 0.18
Median age at first event (years) 53.64 50.63 59.68

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: E4_ADDISON – Adrenocortical insufficiency

GWS hits: 1

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