Drug-induced adrenocortical insufficiency

DRUGADVERS_ADRENOCORTICAL_INSUFFICIENCY

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E27.3#

1 out of 7 registries used, show all original rules.

455

4. Check minimum number of events

None

455

5. Include endpoints

None

455

6. Filter based on genotype QC (FinnGen only)

441

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2471 1595 868
Only index persons 2275 1493 782
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.02
Only index persons 0.05 0.05 0.03
Median age at first event (years)
Whole population 57.01 57.43 56.23
Only index persons 58.04 57.88 58.36

-FinnGen-

Key figures

All Female Male
Number of individuals 441 308 133
Unadjusted period prevalence (%) 0.12 0.13 0.07
Median age at first event (years) 57.76 55.03 64.09

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: DRUGADVERS_ADRENOCORTICAL_INSUFFICIENCY – Drug-induced adrenocortical insufficiency

GWS hits: -

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