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Guillain-Barre syndrome

DOID EFO Endpoint Browser PheWeb

G6_GUILBAR

Guillain-Barre syndrome: Guillain-BarrC) syndrome (GBS) is the term used to describe a spectrum of rare post-infectious neuropathies that usually occur in otherwise healthy patients. GBS is clinically heterogeneous and encompasses acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy (AMAN) and acute motor-sensory axonal neuropathy (AMSAN), Miller-Fisher syndrome (MFS; see these terms) and some other regional variants.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G61.0
  • Hospital discharge: ICD-9 — 3570
  • Hospital discharge: ICD-8 — 35401
  • Cause of death: ICD-10 — G61.0
  • Cause of death: ICD-9 — 3570
  • Cause of death: ICD-8 — 35401

2 out of 7 registries used, show all original rules.

465

4. Check minimum number of events

None

465

5. Include endpoints

None

465

6. Filter based on genotype QC (FinnGen only)

445

Control definitions (FinnGen only)

Control exclude G6_POLYNEU

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G61
Name in latin Syndroma Guillain-Barré

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4635 2063 2535
Only index persons 3894 1777 2117
Unadjusted period prevalence (%)
Whole population 0.07 0.06 0.07
Only index persons 0.07 0.07 0.08
Median age at first event (years)
Whole population 50.92 49.00 52.39
Only index persons 48.14 46.19 49.78

-FinnGen-

Key figures

All Female Male
Number of individuals 445 202 243
Unadjusted period prevalence (%) 0.11 0.09 0.13
Median age at first event (years) 50.70 46.53 54.17

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: G6_GUILBAR – Guillain-Barre syndrome

GWS hits: -

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