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Myasthenia gravis

DOID EFO Endpoint Browser PheWeb

G6_MYASTHENIA

Myasthenia gravis: Myasthenia gravis (MG) is a rare, clinically heterogeneous, autoimmune disorder of the neuromuscular junction characterized by fatigable weakness of voluntary muscles.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G70.0#
  • Hospital discharge: ICD-9 — 3580
  • Hospital discharge: ICD-8 — 7330
  • Cause of death: ICD-10 — G70.0#
  • Cause of death: ICD-9 — 3580
  • Cause of death: ICD-8 — 7330
  • KELA reimbursements: KELA codes — 108

3 out of 7 registries used, show all original rules.

480

4. Check minimum number of events

None

480

5. Include endpoints

None

480

6. Filter based on genotype QC (FinnGen only)

461

Control definitions (FinnGen only)

Control exclude G6_MYONEU

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G70

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3518 1791 1681
Only index persons 2942 1550 1392
Unadjusted period prevalence (%)
Whole population 0.05 0.05 0.05
Only index persons 0.06 0.06 0.05
Median age at first event (years)
Whole population 56.01 50.07 62.40
Only index persons 54.55 48.24 61.57

-FinnGen-

Key figures

All Female Male
Number of individuals 461 246 215
Unadjusted period prevalence (%) 0.11 0.11 0.12
Median age at first event (years) 53.39 46.13 61.70

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: G6_MYASTHENIA – Myasthenia gravis

GWS hits: 1

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