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Hypersensitivity angiitis

DOID EFO Endpoint Browser PheWeb

M13_HYPERANG

hypersensitivity vasculitis: Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M31.0
  • Hospital discharge: ICD-9 — 4462A
  • Hospital discharge: ICD-8 — 4461
  • Cause of death: ICD-10 — M31.0
  • Cause of death: ICD-9 — 4462A
  • Cause of death: ICD-8 — 4461

2 out of 7 registries used, show all original rules.

149

4. Check minimum number of events

None

149

5. Include endpoints

None

149

6. Filter based on genotype QC (FinnGen only)

146

Control definitions (FinnGen only)

Control exclude M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M31
Name in latin Angi(i)tis hypersensitivitatis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1066 579 476
Only index persons 811 452 359
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.01
Only index persons 0.02 0.02 0.01
Median age at first event (years)
Whole population 60.49 61.23 59.53
Only index persons 57.92 58.46 57.23

-FinnGen-

Key figures

All Female Male
Number of individuals 146 70 76
Unadjusted period prevalence (%) 0.04 0.03 0.04
Median age at first event (years) 57.81 56.09 59.39

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: M13_HYPERANG – Hypersensitivity angiitis

GWS hits: -

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