Vascular dementia (sudden onset)

VD_SO

vascular dementia: A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 F01.0
  • Cause of death: ICD-10 F01.0

2 out of 7 registries used, show all original rules.

167

4. Check minimum number of events

None

167

5. Include endpoints

None

167

6. Filter based on genotype QC (FinnGen only)

157

Control definitions (FinnGen only)

Control exclude F5_DEMENTIA, G6_ALZHEIMER, G6_AD_WIDE

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 F01
Name in latin Dementia vascularis subito incipiens

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3652 1906 1688
Only index persons 2020 1098 922
Unadjusted period prevalence (%)
Whole population 0.05 0.05 0.05
Only index persons 0.04 0.04 0.04
Median age at first event (years)
Whole population 80.97 82.95 78.80
Only index persons 81.43 83.51 78.96

-FinnGen-

Key figures

All Female Male
Number of individuals 157 36 121
Unadjusted period prevalence (%) 0.05 0.02 0.07
Median age at first event (years) 77.72 79.05 77.32

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: VD_SO – Vascular dementia (sudden onset)

GWS hits: -

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