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Dementia

DOID EFO Endpoint Browser PheWeb

F5_DEMENTIA

obsolete_dementia: ['An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.']

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F00-F09
  • Hospital discharge: ICD-9 — 290|3310|4378A
  • Hospital discharge: ICD-8 — 290
  • Cause of death: ICD-10 — F00-F09
  • Cause of death: ICD-9 — 290|3310|4378A
  • Cause of death: ICD-8 — 290
  • KELA reimbursements: KELA codes — 307
  • Medicine purchases: ATC — N06D

4 out of 7 registries used, show all original rules.

19823

4. Check minimum number of events

Min. number of events 3
19823

5. Include endpoints

19854

6. Filter based on genotype QC (FinnGen only)

19157

Control definitions (FinnGen only)

Control exclude F5_ORGANIC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF3

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 412960 252777 155854
Only index persons 305996 191151 114845
Unadjusted period prevalence (%)
Whole population 6.12 7.24 4.35
Only index persons 6.04 7.03 4.38
Median age at first event (years)
Whole population 80.88 81.84 79.37
Only index persons 81.10 82.08 79.47

-FinnGen-

Key figures

All Female Male
Number of individuals 19157 8220 10937
Unadjusted period prevalence (%) 4.97 3.57 6.02
Median age at first event (years) 78.77 79.08 78.53

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: F5_DEMENTIA – Dementia

GWS hits: 15

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