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Dementia in Alzheimer disease

DOID EFO Endpoint Browser PheWeb

F5_ALZHDEMENT

Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F00*
  • Hospital discharge: ICD-8 — 29010
  • Cause of death: ICD-10 — F00*
  • Cause of death: ICD-8 — 29010

2 out of 7 registries used, show all original rules.

6344

4. Check minimum number of events

None

6344

5. Include endpoints

None

6344

6. Filter based on genotype QC (FinnGen only)

6145

Control definitions (FinnGen only)

Control exclude F5_ORGANIC

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 128670 81960 45831
Only index persons 110175 71387 38788
Unadjusted period prevalence (%)
Whole population 1.96 2.35 1.28
Only index persons 2.22 2.62 1.48
Median age at first event (years)
Whole population 82.30 83.00 81.09
Only index persons 82.63 83.30 81.39

-FinnGen-

Key figures

All Female Male
Number of individuals 6145 2733 3412
Unadjusted period prevalence (%) 1.57 1.19 1.88
Median age at first event (years) 80.42 80.34 80.48

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: F5_ALZHDEMENT – Dementia in Alzheimer disease

GWS hits: 8

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