Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditionsNone |
429209 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
4 out of 7 registries used, show all original rules. |
16156 |
4. Check minimum number of events
Min. number of events
3
|
16156 |
5. Include endpoints |
16156 |
6. Filter based on genotype QC (FinnGen only) |
15617 |
Control definitions (FinnGen only)
Control exclude
G6_ALZHEIMER
Extra metadata
First used in FinnGen datafreeze
DF3
Alzheimer’s disease, wide definition
based on the number of shared cases.
Broader endpoints:
Narrower endpoints:
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 15617 | 6875 | 8742 |
| Unadjusted period prevalence (%) | 4.01 | 2.99 | 4.81 |
| Median age at first event (years) | 79.07 | 79.16 | 79.00 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: G6_AD_WIDE – Alzheimer’s disease, wide definition
GWS hits: 21
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