Alzheimer disease


Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

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Endpoint definition

Endpoint definition steps


Phenotype data


1. Apply sex-specific rule



2. Check conditions



3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G30
  • Hospital discharge: ICD-9 3310
  • Cause of death: ICD-10 G30
  • Cause of death: ICD-9 3310

2 out of 7 registries used, show all original rules.


4. Check minimum number of events



5. Include endpoints



6. Filter based on genotype QC (FinnGen only)


Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G30-G32
Name in latin Morbus Alzheimer

Similar endpoints

List of similar endpoints to Alzheimer disease based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics


This endpoint is excluded from FinRegistry analyses (omitted endpoint).


Key figures

All Female Male
Number of individuals 10520 4620 5900
Unadjusted period prevalence (%) 2.70 2.01 3.25
Median age at first event (years) 80.14 80.00 80.25


Age distribution of first events


Year distribution of first events


Cumulative Incidence Function

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: G6_ALZHEIMER – Alzheimer disease

GWS hits: 16

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