Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditionsNone |
429209 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
10889 |
4. Check minimum number of eventsNone |
10889 |
5. Include endpointsNone |
10889 |
6. Filter based on genotype QC (FinnGen only) |
10520 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G30-G32
Name in latin
Morbus Alzheimer
Similar endpoints
↥List of similar endpoints to
Alzheimer disease
based on the number of shared cases.
Broader endpoints:
- Alzheimer disease (more control exclusions)
- Other degenerative diseases of the nervous system
- Alzheimer disease, including avohilmo
- Other degenerative diseases of the nervous system
- Alzheimer’s disease, wide definition (more control exclusions)
Narrower endpoints:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 10520 | 4620 | 5900 |
| Unadjusted period prevalence (%) | 2.70 | 2.01 | 3.25 |
| Median age at first event (years) | 80.14 | 80.00 | 80.25 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: G6_ALZHEIMER – Alzheimer disease
GWS hits: 16
Loading Relationships table