Vascular dementia

F5_VASCDEM

vascular dementia: A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 F01
  • Hospital discharge: ICD-9 4378
  • Cause of death: ICD-10 F01
  • Cause of death: ICD-9 4378

2 out of 7 registries used, show all original rules.

2802

4. Check minimum number of events

None

2802

5. Include endpoints

None

2802

6. Filter based on genotype QC (FinnGen only)

2717

Control definitions (FinnGen only)

Control exclude F5_DEMENTIA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F00-F03
Name in latin Dementia vascularis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 65659 37270 27252
Only index persons 40397 23852 16545
Unadjusted period prevalence (%)
Whole population 0.94 1.07 0.76
Only index persons 0.78 0.88 0.63
Median age at first event (years)
Whole population 82.41 84.09 80.27
Only index persons 83.66 85.41 81.13

-FinnGen-

Key figures

All Female Male
Number of individuals 2717 907 1810
Unadjusted period prevalence (%) 0.79 0.39 1.00
Median age at first event (years) 80.44 82.50 79.41

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: F5_VASCDEM – Vascular dementia

GWS hits: 3

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