Vascular dementia (subcortical)

VD_SC

vascular dementia: A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions.

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Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	429209
1. Apply sex-specific rule None	429209
2. Check conditions None	429209
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — F01.2 Cause of death: ICD-10 — F01.2 2 out of 7 registries used, show all original rules.	756
4. Check minimum number of events None	756
5. Include endpoints None	756
6. Filter based on genotype QC (FinnGen only)	735

Control definitions (FinnGen only)

Control exclude F5_DEMENTIA, G6_ALZHEIMER, G6_AD_WIDE

Extra metadata

First used in FinnGen datafreeze DF2

Parent code in ICD-10 F01

Name in latin Dementia vascularis subcorticalis

NAME	VD_SC
CONTROL_EXCLUDE	F5_DEMENTIA\|G6_ALZHEIMER\|G6_AD_WIDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	F012
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	F012
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Vascular dementia (subcortical) based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	12884	7551	5236
Only index persons	10927	6528	4399
Unadjusted period prevalence (%)
Whole population	0.19	0.22	0.15
Only index persons	0.21	0.24	0.17
Median age at first event (years)
Whole population	82.23	83.77	80.07
Only index persons	82.70	84.21	80.45

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	735	274	461
Unadjusted period prevalence (%)	0.20	0.12	0.25
Median age at first event (years)	80.64	82.15	79.75

≡ Risteys

FR+FG R10

FinnGen Risteys R10

FinnGen Risteys R9

FinnGen Risteys R8

FinnGen Risteys R7

FinnGen Risteys R6

FinnGen Risteys R5

FinnGen Risteys R4

FinnGen Risteys R3

Vascular dementia (subcortical)

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Vascular dementia (subcortical) (VD_SC)

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints