age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditions
|
429121 |
3. Check pre-conditions, main-only, mode, registry filtersPre-conditions: EVENT_AGE>=50 Registry filters:
2 out of 7 registries used, show all original rules. |
5424 |
4. Check minimum number of eventsNone |
5424 |
5. Include endpointsNone |
5424 |
6. Filter based on genotype QC (FinnGen only) |
5239 |
Control definitions (FinnGen only)
Control exclude
H7_RETINOPATHYDIAB, H7_RETINASEPAR, MACULA_NAS, H7_GLAUCPRIMOPEN, H7_GLAUCCLOSEPRIM, H7_GLAUCSECTRAUMA, H7_GLAUCSECINFLAM, H7_GLAUCSECDISEASE, H7_GLAUCSECDRUG, H7_GLAUCNAS
Control pre-conditions
DEATH_AGE>=50
Control conditions
not WET_AMD_EARLY
Extra metadata
Level in the ICD hierarchy
5
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H35
Name in latin
Degeneratio maculae senilis exsudativa
Similar endpoints
↥List of similar endpoints to
Wet age-related macular degeneration
based on the number of shared cases.
Broader endpoints:
- Age-related macular degeneration (whether dry or wet)
- Degeneration of macula and posterior pole
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
Narrower endpoints:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 55712 | 35752 | 19781 |
| Only index persons | 52323 | 33890 | 18433 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.85 | 1.02 | 0.55 |
| Only index persons | 1.05 | 1.25 | 0.70 |
| Median age at first event (years) | |||
| Whole population | 79.09 | 80.01 | 77.43 |
| Only index persons | 79.02 | 79.96 | 77.30 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 5239 | 2660 | 2579 |
| Unadjusted period prevalence (%) | 1.28 | 1.16 | 1.42 |
| Median age at first event (years) | 76.52 | 76.69 | 76.34 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Relationships between endpoints
↥Index endpoint: WET_AMD – Wet age-related macular degeneration
GWS hits: 22
Loading Relationships table