Drug-induced osteoporosis with pathological fracture

OSTPOPATFRACTURE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M80.4#
  • Cause of death: ICD-10 M80.4#

2 out of 7 registries used, show all original rules.

395

4. Check minimum number of events

None

395

5. Include endpoints

None

395

6. Filter based on genotype QC (FinnGen only)

388

Control definitions (FinnGen only)

Control exclude OSTEOPOROSIS_FRACTURE_FG

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 M80
Name in latin Osteoporosis e medicamento cum fractura pathologica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2573 1758 796
Only index persons 2250 1568 682
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.02
Only index persons 0.05 0.06 0.03
Median age at first event (years)
Whole population 70.33 71.59 67.62
Only index persons 70.23 71.36 67.63

-FinnGen-

Key figures

All Female Male
Number of individuals 388 275 113
Unadjusted period prevalence (%) 0.10 0.12 0.06
Median age at first event (years) 67.91 67.74 68.31

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: OSTPOPATFRACTURE – Drug-induced osteoporosis with pathological fracture

GWS hits: -

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