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Osteoporosis

DOID EFO Endpoint Browser PheWeb

M13_OSTEOPOROSIS

osteoporosis: A condition of reduced bone mass, with decreased cortical thickness and a decrease in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. Osteoporosis is classified as primary (Type 1, postmenopausal osteoporosis; Type 2, age-associated osteoporosis; and idiopathic, which can affect juveniles, premenopausal women, and middle-aged men) and secondary osteoporosis (which results from an identifiable cause of bone mass loss).

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M80, M81, M82*
  • Hospital discharge: ICD-9 — 733[0-1]
  • Hospital discharge: ICD-8 — 7230|72391
  • Cause of death: ICD-10 — M80, M81, M82*
  • Cause of death: ICD-9 — 733[0-1]
  • Cause of death: ICD-8 — 7230|72391

2 out of 7 registries used, show all original rules.

8275

4. Check minimum number of events

None

8275

5. Include endpoints

None

8275

6. Filter based on genotype QC (FinnGen only)

8017

Control definitions (FinnGen only)

Control exclude M13_OSTEOCHONDRO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 100074 81572 18008
Only index persons 85098 69843 15255
Unadjusted period prevalence (%)
Whole population 2.00 2.34 0.50
Only index persons 2.21 2.57 0.58
Median age at first event (years)
Whole population 76.25 77.58 70.28
Only index persons 75.89 77.28 69.49

-FinnGen-

Key figures

All Female Male
Number of individuals 8017 6084 1933
Unadjusted period prevalence (%) 2.26 2.64 1.06
Median age at first event (years) 69.96 70.20 69.20

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: M13_OSTEOPOROSIS – Osteoporosis

GWS hits: 6

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