Substance abuse (more control exclusions)

KRA_PSY_SUBSTANCE_EXMORE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 F10-F19
  • Hospital discharge: ICD-9 29[1-2]|30[3-5]
  • Hospital discharge: ICD-8 291|30[3-4]
  • Hospital discharge: excluded ICD-10 F10.0
  • Hospital discharge: excluded ICD-9 3050A
  • Cause of death: ICD-10 F10-F19
  • Cause of death: ICD-9 29[1-2]|30[3-5]
  • Cause of death: ICD-8 291|30[3-4]

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude KRA_PSY_ANYMENTAL

Extra metadata

First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

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Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 402168 113244 284097
Only index persons 303852 97092 206760
Unadjusted period prevalence (%)
Whole population 6.58 3.24 7.94
Only index persons 6.51 3.57 7.89
Median age at first event (years)
Whole population 43.02 41.93 43.34
Only index persons 41.43 40.24 42.00

-FinnGen-

Key figures

All Female Male
Number of individuals 25458 9086 16372
Unadjusted period prevalence (%) 7.20 3.95 9.00
Median age at first event (years) 44.98 40.84 47.28

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: KRA_PSY_SUBSTANCE_EXMORE – Substance abuse (more control exclusions)

GWS hits: 18

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