Any mental disorder

KRA_PSY_ANYMENTAL

vascular dementia: A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 F0[0-3]|F051|G30|F[1-9]
  • Hospital discharge: ICD-9 29[0-2]|2941A|29[5-9]|30|31[2-9]|3310A|3311A|4378A
  • Hospital discharge: ICD-8 29[0-1]|29440|29[5-9]|30[0-1]|3021|30[3-8]|310
  • Cause of death: ICD-10 F0[0-3]|F051|G30|F[1-9]
  • Cause of death: ICD-9 29[0-2]|2941A|29[5-9]|30|31[2-9]|3310A|3311A|4378A
  • Cause of death: ICD-8 29[0-1]|29440|29[5-9]|30[0-1]|3021|30[3-8]|310

2 out of 7 registries used, show all original rules.

113836

4. Check minimum number of events

None

113836

5. Include endpoints

114939

6. Filter based on genotype QC (FinnGen only)

110300

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF9

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1752582 883234 853645
Only index persons 1407999 748063 659936
Unadjusted period prevalence (%)
Whole population 24.51 25.30 23.85
Only index persons 26.42 27.50 25.19
Median age at first event (years)
Whole population 40.42 43.71 36.80
Only index persons 37.04 39.98 33.71

-FinnGen-

Key figures

All Female Male
Number of individuals 110300 63110 47190
Unadjusted period prevalence (%) 26.79 27.41 25.96
Median age at first event (years) 42.45 38.83 47.28

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: KRA_PSY_ANYMENTAL – Any mental disorder

GWS hits: 27

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