Vascular syndromes of brain in cerebrovascular disorders

I9_VASCSYND

cerebrovascular disorder: A disorder resulting from inadequate blood flow in the vessels that supply the brain. Representative examples include cerebrovascular ischemia, cerebral embolism, and cerebral infarction.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G46*
  • Cause of death: ICD-10 G46*

2 out of 7 registries used, show all original rules.

1328

4. Check minimum number of events

None

1328

5. Include endpoints

None

1328

6. Filter based on genotype QC (FinnGen only)

1283

Control definitions (FinnGen only)

Control exclude F5_DEMENTIA, G6_ALZHEIMER, G6_AD_WIDE

Extra metadata

First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 16266 7420 8756
Only index persons 13791 6353 7438
Unadjusted period prevalence (%)
Whole population 0.23 0.21 0.24
Only index persons 0.26 0.23 0.28
Median age at first event (years)
Whole population 72.14 75.72 69.09
Only index persons 71.24 74.84 68.16

-FinnGen-

Key figures

All Female Male
Number of individuals 1283 519 764
Unadjusted period prevalence (%) 0.34 0.23 0.42
Median age at first event (years) 68.35 66.33 69.72

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: I9_VASCSYND – Vascular syndromes of brain in cerebrovascular disorders

GWS hits: -

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