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Heart failure,strict (more control exclusions)

Endpoint Browser PheWeb

I9_HEARTFAIL_EXMORE

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I11.0, I13.0, I13.2, I50
  • Hospital discharge: ICD-9 — 4029B|428
  • Hospital discharge: ICD-8 — 42700|42710|428|7824
  • Cause of death: ICD-10 — I11.0, I13.0, I13.2, I50
  • Cause of death: ICD-9 — 4029B|428
  • Cause of death: ICD-8 — 42700|42710|428|7824
  • KELA reimbursements: KELA codes — 201
  • Medicine purchases: ATC — C03CA01|C03EB01

4 out of 7 registries used, show all original rules.

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4. Check minimum number of events

Min. number of events 3, and need other rules
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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude I9_HEARTFAIL_NS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF6

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 488284 258381 222422
Only index persons 306110 164935 141175
Unadjusted period prevalence (%)
Whole population 6.87 7.40 6.21
Only index persons 5.75 6.06 5.39
Median age at first event (years)
Whole population 73.72 75.74 71.47
Only index persons 74.89 77.35 72.00

-FinnGen-

Key figures

All Female Male
Number of individuals 29672 10805 18867
Unadjusted period prevalence (%) 8.31 4.69 10.38
Median age at first event (years) 71.07 71.45 70.85

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: I9_HEARTFAIL_EXMORE – Heart failure,strict (more control exclusions)

GWS hits: 10

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