Heart failure,strict

I9_HEARTFAIL

systolic heart failure: Heart failure caused by abnormal myocardial contraction during systole leading to defective cardiac emptying.

Suggest a new description

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	429209
1. Apply sex-specific rule None	429209
2. Check conditions None	429209
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — I11.0, I13.0, I13.2, I50 Hospital discharge: ICD-9 — 4029B\|428 Hospital discharge: ICD-8 — 42700\|42710\|428\|7824 Cause of death: ICD-10 — I11.0, I13.0, I13.2, I50 Cause of death: ICD-9 — 4029B\|428 Cause of death: ICD-8 — 42700\|42710\|428\|7824 KELA reimbursements: KELA codes — 201 Medicine purchases: ATC — C03CA01\|C03EB01 4 out of 7 registries used, show all original rules.	30702
4. Check minimum number of events Min. number of events 3, and need other rules	30702
5. Include endpoints None	30702
6. Filter based on genotype QC (FinnGen only)	29672

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF6

NAME	I9_HEARTFAIL
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	I50\|I110\|I130\|I132
HD_ICD_9	4029B\|428
HD_ICD_8	42700\|42710\|428\|7824
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	I50\|I110\|I130\|I132
COD_ICD_9	4029B\|428
COD_ICD_8	42700\|42710\|428\|7824
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB	201
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER	YES
KELA_ATC	C03CA01\|C03EB01
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Heart failure,strict based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	488284	258381	222422
Only index persons	306110	164935	141175
Unadjusted period prevalence (%)
Whole population	6.87	7.40	6.21
Only index persons	5.75	6.06	5.39
Median age at first event (years)
Whole population	73.72	75.74	71.47
Only index persons	74.89	77.35	72.00

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	29672	10805	18867
Unadjusted period prevalence (%)	8.31	4.69	10.38
Median age at first event (years)	71.07	71.45	70.85

≡ Risteys

FR+FG R10

FinnGen Risteys R10

FinnGen Risteys R9

FinnGen Risteys R8

FinnGen Risteys R7

FinnGen Risteys R6

FinnGen Risteys R5

FinnGen Risteys R4

FinnGen Risteys R3

Heart failure,strict

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Heart failure,strict (I9_HEARTFAIL)

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints