Hypothyroidism, drug reimbursement

HYPOTHY_REIMB

hypothyroidism: Abnormally low levels of thyroid hormone.

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	429209
1. Apply sex-specific rule None	429209
2. Check conditions None	429209
3. Check pre-conditions, main-only, mode, registry filters Registry filters: KELA reimbursements: KELA codes — 104 1 out of 7 registries used, show all original rules.	13880
4. Check minimum number of events None	13880
5. Include endpoints None	13880
6. Filter based on genotype QC (FinnGen only)	13428

Control definitions (FinnGen only)

Control exclude E4_MALNUTRITION, E4_DIABETES, I9_CVD, C3_CANCER, MENINGITIS, ENCEPHALITIS, HYPOTHYROIDISM, D3_ANAEMIA, F5_ALLANXIOUS, F5_MOOD, F5_SCHIZO, F5_BEHEMOCHILD, F5_UNSMENDIS, ANOSMIA, ANTIDEPRESSANTS

Extra metadata

First used in FinnGen datafreeze DF3

NAME	HYPOTHY_REIMB
CONTROL_EXCLUDE	E4_MALNUTRITION\|E4_DIABETES\|I9_CVD\|C3_CANCER\|MENINGITIS\|ENCEPHALITIS\|HYPOTHYROIDISM\|D3_ANAEMIA\|F5_ALLANXIOUS\|F5_MOOD\|F5_SCHIZO\|F5_BEHEMOCHILD\|F5_UNSMENDIS\|ANOSMIA\|ANTIDEPRESSANTS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB	104
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Hypothyroidism, drug reimbursement based on the number of shared cases.

Broader endpoints:

Any reimbursement code in KELA

Narrower endpoints:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	127566	105615	21123
Only index persons	107457	90351	17106
Unadjusted period prevalence (%)
Whole population	2.61	3.03	0.59
Only index persons	2.90	3.32	0.65
Median age at first event (years)
Whole population	51.91	51.67	52.89
Only index persons	49.93	49.83	50.42

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	13428	11093	2335
Unadjusted period prevalence (%)	4.20	4.82	1.28
Median age at first event (years)	47.84	46.68	53.33

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: HYPOTHY_REIMB – Hypothyroidism, drug reimbursement

GWS hits: 27

Loading Relationships table

≡ Risteys

FR+FG R10

FinnGen Risteys R10

FinnGen Risteys R9

FinnGen Risteys R8

FinnGen Risteys R7

FinnGen Risteys R6

FinnGen Risteys R5

FinnGen Risteys R4

FinnGen Risteys R3

Hypothyroidism, drug reimbursement

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Hypothyroidism, drug reimbursement (HYPOTHY_REIMB)

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints