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Parkinson's disease, strict definition

DOID Endpoint Browser

PDSTRICT

secondary Parkinson disease: Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected condition. Examples include parkinsonism caused by vascular injury, drugs, trauma, toxin exposure, neoplasms, infections and degenerative or hereditary conditions. Clinical features may include bradykinesia, rigidity, parkinsonian gait, and masked facies. In general, tremor is less prominent in secondary parkinsonism than in the primary form. (From Joynt, Clinical Neurology, 1998, Ch38, pp39-42)

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G20
  • Hospital discharge: ICD-9 — 3320A
  • Hospital discharge: ICD-8 — 34200
  • Cause of death: ICD-10 — G20
  • Cause of death: ICD-9 — 3320A
  • Cause of death: ICD-8 — 34200
  • KELA reimbursements: KELA codes — 110
  • KELA reimbursements: ICD-10 — G20, G20+F02.39

3 out of 7 registries used, show all original rules.

4347

4. Check minimum number of events

None

4347

5. Include endpoints

None

4347

6. Filter based on genotype QC (FinnGen only)

4231

Control definitions (FinnGen only)

Control exclude G6_PARKINSON

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 G20-G26
Name in latin Morbus Parkinson

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 4231 1651 2580
Unadjusted period prevalence (%) 1.15 0.72 1.42
Median age at first event (years) 70.09 69.19 70.66

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

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This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: PDSTRICT – Parkinson's disease, strict definition

GWS hits: -

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