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Parkinson's disease

DOID Endpoint Browser PheWeb

G6_PARKINSON

Parkinson's disease: A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G20
  • Hospital discharge: ICD-9 — 3320A
  • Hospital discharge: ICD-8 — 34200
  • Cause of death: ICD-10 — G20
  • Cause of death: ICD-9 — 3320A
  • Cause of death: ICD-8 — 34200
  • KELA reimbursements: KELA codes — 110

3 out of 7 registries used, show all original rules.

4806

4. Check minimum number of events

None

4806

5. Include endpoints

None

4806

6. Filter based on genotype QC (FinnGen only)

4681

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G20-G26
Name in latin Morbus Parkinson

Similar endpoints

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Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 4681 1858 2823
Unadjusted period prevalence (%) 1.26 0.81 1.55
Median age at first event (years) 68.77 67.11 69.86

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: G6_PARKINSON – Parkinson's disease

GWS hits: 5

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