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Gonarthrosis

DOID EFO Endpoint Browser PheWeb

M13_ARTHROSIS_KNEE

spondyloarthropathy: A group of inflammatory rheumatic diseases associated with arthritis and enthesitis, and often involving the axial skeleton. The most common form of spondyloarthritis is ankylosing spondylitis. Other forms include axial spondyloarthritis, peripheral spondyloarthritis, reactive arthritis, psoriatic arthritis/spondylitis and enteropathic arthritis/spondylitis.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M17
  • Hospital discharge: ICD-9 — 7151F|7152F
  • Hospital discharge: ICD-8 — 71301
  • Cause of death: ICD-10 — M17
  • Cause of death: ICD-9 — 7151F|7152F
  • Cause of death: ICD-8 — 71301

2 out of 7 registries used, show all original rules.

50213

4. Check minimum number of events

None

50213

5. Include endpoints

None

50213

6. Filter based on genotype QC (FinnGen only)

48835

Control definitions (FinnGen only)

Control exclude M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M15-M19
Name in latin Gonarthrosis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 449784 273379 174237
Only index persons 403176 246336 156840
Unadjusted period prevalence (%)
Whole population 6.66 7.83 4.87
Only index persons 7.86 9.06 5.99
Median age at first event (years)
Whole population 61.87 63.63 59.06
Only index persons 60.94 62.59 58.36

-FinnGen-

Key figures

All Female Male
Number of individuals 48835 28750 20085
Unadjusted period prevalence (%) 11.89 12.49 11.05
Median age at first event (years) 59.26 59.13 59.45

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: M13_ARTHROSIS_KNEE – Gonarthrosis

GWS hits: 70

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