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Non-rheumatic valve diseases

DOID EFO Endpoint Browser PheWeb

I9_NONRHEVALV

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I34, I35, I36, I37
  • Hospital discharge: ICD-9 — 424
  • Hospital discharge: ICD-8 — 39[4-6]|424
  • Hospital discharge: excluded ICD-8 — 4249|3940|3950|3960|3970
  • Cause of death: ICD-10 — I34, I35, I36, I37
  • Cause of death: ICD-9 — 424
  • Cause of death: ICD-8 — 39[4-6]|424
  • Cause of death: excluded ICD-8 — 4249|3940|3950|3960|3970

2 out of 7 registries used, show all original rules.

23434

4. Check minimum number of events

None

23434

5. Include endpoints

None

23434

6. Filter based on genotype QC (FinnGen only)

22652

Control definitions (FinnGen only)

Control exclude I9_OTHHEART

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 215676 107164 106544
Only index persons 175595 87966 87629
Unadjusted period prevalence (%)
Whole population 3.01 3.07 2.98
Only index persons 3.29 3.23 3.35
Median age at first event (years)
Whole population 71.82 74.38 69.26
Only index persons 71.28 73.70 68.86

-FinnGen-

Key figures

All Female Male
Number of individuals 22652 9549 13103
Unadjusted period prevalence (%) 5.92 4.15 7.21
Median age at first event (years) 68.88 69.04 68.77

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: I9_NONRHEVALV – Non-rheumatic valve diseases

GWS hits: 10

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