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Schizophrenia

DOID EFO Endpoint Browser PheWeb

F5_SCHZPHR

schizophrenia: A major psychotic disorder characterized by abnormalities in the perception or expression of reality. It affects the cognitive and psychomotor functions. Common clinical signs and symptoms include delusions, hallucinations, disorganized thinking, and retreat from reality.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F20
  • Hospital discharge: ICD-9 — 295
  • Hospital discharge: ICD-8 — 295
  • Hospital discharge: excluded ICD-9 — 2954|2957
  • Hospital discharge: excluded ICD-8 — 2957
  • Cause of death: ICD-10 — F20
  • Cause of death: ICD-9 — 295
  • Cause of death: ICD-8 — 295
  • Cause of death: excluded ICD-9 — 2954|2957
  • Cause of death: excluded ICD-8 — 2957

2 out of 7 registries used, show all original rules.

6976

4. Check minimum number of events

None

6976

5. Include endpoints

None

6976

6. Filter based on genotype QC (FinnGen only)

6707

Control definitions (FinnGen only)

Control exclude F5_SCHIZO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F20-F29
Name in latin Schizophrenia

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 69834 33018 36128
Only index persons 55372 26366 29006
Unadjusted period prevalence (%)
Whole population 0.98 0.95 1.01
Only index persons 1.04 0.97 1.11
Median age at first event (years)
Whole population 33.95 37.21 30.80
Only index persons 32.39 35.12 29.90

-FinnGen-

Key figures

All Female Male
Number of individuals 6707 3014 3693
Unadjusted period prevalence (%) 1.71 1.31 2.03
Median age at first event (years) 29.17 30.01 28.48

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: F5_SCHZPHR – Schizophrenia

GWS hits: 1

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