Depression or dysthymia

F5_DEPRESSION_DYSTHYMIA

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

  • not (F5_SCHIZO
  • or F5_SCHIZOAFF
  • or F5_BIPO
409530

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 F32, F33, F34.1
  • Hospital discharge: ICD-10 F32, F33, F34.1
  • Hospital discharge: ICD-9 2961|2968|3004
  • Cause of death: ICD-10 F32, F33
  • Cause of death: ICD-9 2961|2968|3004

3 out of 7 registries used, show all original rules.

57135

4. Check minimum number of events

None

57135

5. Include endpoints

None

57135

6. Filter based on genotype QC (FinnGen only)

54732

Control definitions (FinnGen only)

Control exclude F5_PSYCH, ANTIDEPRESSANTS

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF9

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 637991 396948 236715
Only index persons 592359 374888 217471
Unadjusted period prevalence (%)
Whole population 9.56 11.37 6.61
Only index persons 11.77 13.78 8.30
Median age at first event (years)
Whole population 40.11 40.06 40.21
Only index persons 38.67 38.62 38.77

-FinnGen-

Key figures

All Female Male
Number of individuals 54732 38351 16381
Unadjusted period prevalence (%) 14.37 16.65 9.01
Median age at first event (years) 44.97 42.96 49.67

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: F5_DEPRESSION_DYSTHYMIA – Depression or dysthymia

GWS hits: 32

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