hyperpituitarism: Disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone ; and adrenocorticotropic hormone. Hyperpituitarism usually is caused by a functional adenoma.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditionsNone |
429209 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1501 |
4. Check minimum number of eventsNone |
1501 |
5. Include endpoints |
1656 |
6. Filter based on genotype QC (FinnGen only) |
1585 |
Control definitions (FinnGen only)
Control exclude
E4_ENDOGLAND
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E20-E35
Name in latin
Hyperfunctio hypophysis
Similar endpoints
↥List of similar endpoints to
Hyperfunction of pituitary gland
based on the number of shared cases.
Broader endpoints:
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Narrower endpoints:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13775 | 10007 | 3602 |
| Only index persons | 12382 | 9265 | 3117 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.24 | 0.29 | 0.10 |
| Only index persons | 0.28 | 0.34 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 36.03 | 32.93 | 44.58 |
| Only index persons | 35.04 | 32.51 | 42.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1585 | 1213 | 372 |
| Unadjusted period prevalence (%) | 0.45 | 0.53 | 0.20 |
| Median age at first event (years) | 37.97 | 34.40 | 49.60 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Relationships between endpoints
↥Index endpoint: E4_HYPERPIT – Hyperfunction of pituitary gland
GWS hits: -
Loading Relationships table