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Syndrome of inappropriate secretion of antidiuretic hormone

DOID EFO Endpoint Browser PheWeb

E4_ANTIDIU

inappropriate ADH syndrome: A syndrome characterized by abnormal secretion of antidiuretic hormone in conjunction with neoplastic growth occurring anywhere in the body.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E22.2
  • Hospital discharge: ICD-9 — 2536X
  • Cause of death: ICD-10 — E22.2
  • Cause of death: ICD-9 — 2536X

2 out of 7 registries used, show all original rules.

137

4. Check minimum number of events

None

137

5. Include endpoints

None

137

6. Filter based on genotype QC (FinnGen only)

133

Control definitions (FinnGen only)

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E22
Name in latin Syndroma secretionis impropriae hormonis antidiuretici

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1631 971 648
Only index persons 1405 854 551
Unadjusted period prevalence (%)
Whole population 0.02 0.03 0.02
Only index persons 0.03 0.03 0.02
Median age at first event (years)
Whole population 71.56 74.37 67.48
Only index persons 72.04 74.92 67.57

-FinnGen-

Key figures

All Female Male
Number of individuals 133 66 67
Unadjusted period prevalence (%) 0.03 0.03 0.04
Median age at first event (years) 68.99 69.08 68.90

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: E4_ANTIDIU – Syndrome of inappropriate secretion of antidiuretic hormone

GWS hits: 1

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